3-Chloropropiophenone, also known as 3-Chloro-1-phenyl-1-propanone or 3-Chloro-1-phenylpropan-1-one, is an important organic compound, often used as a pharmaceutical  intermediate in the synthesis of psychiatric drug molecules. As a derivative of phenylacetone, it has similar physical and chemical properties to phenylacetone and can undergo various chemical conversion reactions, making it widely used in organic synthesis.

Properties of 3-Chloropropiophenone

3-Chloro-1-phenyl-1-propanone is off-white to pale yellow chemical powder at room temperature and pressure. It is stable at room temperature and pressure, easily soluble in ethanol, ether, slightly soluble in Chloroform, methanol and insoluble in water.

Melting point: 48-50 °C(lit.)
Boiling point: 263.3±23.0 °C at 760 mmHg
Flash Point: 127.0±13.7 °C

Applications of 3-Chloropropiophenone

3-Chloro-1-phenylpropan-1-one is a key intermediate in the synthesis of drugs such as bupropion hydrochloride, dapoxetine, and malaviro. It is also used in the synthesis of (S)-3-Chlorophenylpropanol which is an important chiral building block for the synthesis of chiral antidepressant drugs such as Tomoxetine, Fluoxetine, and Nizoxetine. (S)-3-Chlorophenylpropanol is mainly made by asymmetric reduction of 3-Chloropropiophenone.

You can get (S)-3-Chlorophenylpropanol by using 95% ethanol as the solvent, adding KBH4 solid to reduce 3-Chloropropiophenone, followed by cooling and recrystallization of n-hexane. This method takes short time, simple to operation, high purity of the obtained product, low production cost, and is suitable for large-scale production. Of course, it can also be used in laboratory organic synthesis and other chemical production processes.

Storage of 3-Chloropropiophenone

3-Chloro-1-phenyl-1-propanone should be properly stored in a cool, dry place with the container sealed, ensuring good ventilation, and away from oxidants, acids, and edible chemicals.

3-Chloropropiophenone is irritating and harmful, may cause damage to the central nervous system and respiratory system, so it should be handled with caution and in a well ventilated area to avoid inhalation or skin contact. When using or storing, appropriate protective measures should be taken, such as wearing protective gloves, goggles, and masks. In case of accidental contact, immediately rinse the affected area with plenty of water and seek medical attention.